Primary Microcephaly: Do All Roads Lead to Rome?

Samer Mouksassi, Shasha Jumbe, Lifecycle, Auxology, & Neurocognitive Development, Quantitative Physiologic Modeling, and Mother-Fetus Predation teams


  • Symmetric intrauterine growth restriction (IUGR) has a growth pattern where all biometric measurements are affected to the same degree.
  • Asymmetric IUGR has growth with small abdominal circumference (AC) compared with other growth parameters:
    • Abnormal head circumference/AC (HC/AC) ratio
    • Abnormal femur length/AC (FL/AC) ratio.
  • The objectives of this study were:

(1) To determine the joint probability distributions of growth parameters describing Weight/Length and Head Circumference (WT/LEN/HC) from age 0 to 24 mo, and

(2) To study symmetry across the 3 growth measures to provide useful quantitative guidance to Zika clinicians and researchers on measurements of individuals with a normal/mild-to-moderate/small head relative to other anthropometric measures.


25th Annual Meeting of the Population Approach Group in Europe


Neurocognitive Development, Stunting, Wasting

Last Updated

September, 2017



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